Glucose monitoring plays a pivotal role in the diagnosis, treatment, and prognosis of diabetes. Non-invasive glucose monitoring (NGM), which utilizes emerging optical and electrical technologies to achieve glucose monitoring without blood sampling, offers advantages such as being painless and convenient for patients. However, current technologies still face potential challenges regarding accuracy, safety, and reliability. This expert consensus aims to clarify the clinical necessity, key evaluation indicators, technological advantages, and priority populations for the clinical application of NGM, providing reference for its translational development and practical implementation. Experts from endocrinology, laboratory medicine, and related engineering disciplines across China jointly initiated this consensus, which was developed through the Delphi method to systematically integrate expert opinions. The consensus indicates that NGM shows high application potential value in scenarios such as diabetes screening, lifestyle intervention, and monitoring of therapeutic efficacy, but its utility for diagnostic purposes remains limited. Evaluation of NGM technologies should primarily focus on accuracy and stability, while simplicity and safety should also be emphasized in specific clinical contexts. Technological development should prioritize clinical performance and intelligent system capability, while balancing patient experience and accessibility. Priority populations include children and adolescents with diabetes, patients with needle phobia or poor compliance, individuals with type 1 diabetes, and elderly patients with multiple comorbidities. Future technological development of NGM should fully take clinical performance and intelligent system integration as its foundation, while ensuring patient experience and economic accessibility.
